Ctgf target
WebHerein, we propose that CTGF is a promising cancer therapeutic target that could potentially improve the clinical outcomes of cancer patients. Keywords connective tissue … WebApr 11, 2024 · During chronic hepatitis B virus (HBV) infection, hepatic fibrosis is a serious pathological condition caused by virus-induced liver damage. The activation of hepatic stellate cells (HSCs) is a central event in the occurrence and progression of liver fibrosis. Although accumulating evidence has shown that HBV directly stimulates HSC activation, …
Ctgf target
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WebOverexpression of CTGF enhances resistance to 5-FU-promoting cell death. To examine the potential role of CTGF on the regulation of chemoresistance to 5-FU, we first confirmed that the pCDNA3.1-CTGF vector and CTGF small interfering RNA (CTGF-siRNA) were overexpressing and interfering with the protein and mRNA of CTGF in HT-29 and SW620 … WebMar 23, 2024 · As shown in Figure S3C, overexpression of NFATC2 significantly upregulated the expression levels of the target genes of Hippo/YAP signaling pathway (CTGF and Gli2) 18–20 in both HCT-116 and HT-29 cells. Conversely, reduced mRNA expression levels of CTGF and Gli2 were observed in NFATC2-knockdown HCT-116 …
WebAug 9, 2024 · CTGF is not only a mediator of tissue fibrosis but also a potential biological marker and a potential target for the treatment of renal fibrosis. More clinical studies are needed to assess the safety and efficacy of CTGF-neutralizing antibodies in patients with diabetes or non-diabetic kidney disease. WebJul 7, 2008 · National Center for Biotechnology Information
WebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. However, it is not clear ... WebThe CTGF gene is a transcriptional target of both YAP/TAZ and TGFβ-SMAD signaling pathways (6,7), and aberrant regulation of CTGF expression is strongly associated with pathological conditions, notably cancer and fibrosis (8,9). Chen, C.C. and Lau, L.F. (2009) Int J Biochem Cell Biol 41, 771-83.
WebMar 18, 2010 · Connective tissue growth factor (CTGF) is a profibrogenic factor that stimulates fibroblast proliferation, cell adhesion, and extracellular matrix production (9,10). The potential role of CTGF in pathological fibrosis has been established , and CTGF has been suggested to be an attractive therapeutic target in some fibrotic diseases .
WebMar 9, 2024 · Ctgf is the direct target gene of SOX9 in chondrocytes and nucleus pulposus cells. As shown in mouse model of kidney fibrosis CTGF is significantly involved in fibrosis-associated renal lymphangiogenesis through regulation of, and direct interaction with, VEGF-C. CTGF and BMP2 are induced following myocardial ischemia in mice and humans. can i get a suit tailored in one dayWebOct 29, 2024 · CTGF and TGFβ were found to be increased in the alveolar epithelial cells inoculated with SARS-CoV-2 (Xu et al., 2024). As a … can i get a tan when it\u0027s cloudyWebAug 30, 2024 · CTGF expression is increased in renal fibrosis as well as hepatic fibrosis, and a recent study reported CTGF as a new target in renal fibrosis . In addition, autophagy is essential for the maintenance of kidney homeostasis, structure, and function, and dysregulated autophagy contributes to the pathogenesis of various kidney diseases [ 29 ]. fitting orthoticsWebIncreasing evidence emphasizes the notion that CTGF is pivotal in cancer initiation and progression. The interplay of tumor cells and the tumor microenvironment significantly affects the efficacy of therapeutic agents. The functional importance of CTGF provides an opportunity to disrupt ECM-mediated protection and to target tumors directly. can i get a sweatshirt alteredWebMiat can sponge miR-133a-3p in an Ago2-dependent manner, reduce the binding of miR-133a-3p target to the 3ʹUTR region of CTGF mRNA and improve the protein expression level of CTGF. fitting out a tinny for fishingWebMar 10, 2024 · Overall, our work suggests a novel function for CTGF as a modulator of cancer metabolism, indicating that CTGF is a potential therapeutic target in TNBC. … fitting or well-put crossword clueWebCTGF is a direct target of YAP and TEAD. (A) Both YAP and TEAD1 bind to the CTGF promoter. ChIP from MCF10A cells was performed with control IgG, YAP, or TEAD1 antibody as indicated. fitting oring boss