WebA practical strategy for the total stepwise solid-phase synthesis of peptide-oligonucleotide conjugates was developed. In this strategy, the Boc/tBu protecting groups are utilized for the side chains of Trp, His, Arg, Asp, and Glu, and is deprotected in borate buffer at 90 °C to avoid depurination of the oligonucleotide caused by strong acid treatment. WebFeb 8, 2024 · The BOC (tert-butoxycarbonyl) group is used to protect amines in synthetic reactions, is probably the most common amine …

The Reactivity of the N-Boc Protecting Group: An ... - ResearchGate

WebJan 21, 2002 · Several N-Boc protected aromatic compounds are easily deprotected by Bu 4 NF. This method is compatible with several acidic and basic sensitive groups, like esters, aldehydes or maleimides. Selective deprotection could be achieved with substrates containing both aromatic and aliphatic N-Boc groups. Studies are in progress to trap the ... WebBoc-Protected Amino-Groups in Multi-step Syntheses. SmCl 3 is an excellent catalyst for chemoselective esterifications and selective removal of acid sensitive hydroxyl protecting groups such as Boc, THP, and TBDMS. Chemoselective deprotection is … cheap yamaha motorcycles

What is Boc organic chemistry? - scienceoxygen.com

WebThe t-butoxycarbamate (BOC) group is widely used to protect amines, and to a lesser extent alcohols can be protected with BOC groups. Whilst the insertion and removal of … WebMar 13, 2024 · Traditional deprotection strategies involving trifluoroacetic and other protic and Lewis acids proved unsuccessful in removal of the recalcitrant indole- N -Boc … WebThe reaction time for MBHA-resin is typically between 60 and 90 minutes at room temperature. Boc and formyl protecting groups should be removed prior to the cleavage procedure. The procedure is compatible with Asp(OBzl), Glu(OBzl) and Lys(ClZ) protection (Method 7). Please note that the peptide resin should be washed and well dried before … cycling meal plan